Neurological cancers, also referred to as central nervous system (CNS) tumours, arise in the brain or spinal cord. These can be:
Primary tumours, originating in CNS tissues;
Secondary (metastatic) tumours, spreading from cancers elsewhere in the body.
Many of these tumours are non-cancerous, but even non-cancerous tumours can be dangerous due to their growth within delicate neural structures.
CNS tumours are grouped largely by their cellular origin, which influences treatment and prognosis. Common types include:
Gliomas – originate from glial cells and account for around 30% of all CNS tumours and 80% of malignant ones. Subtypes include:
Astrocytomas (e.g., glioblastoma, pilocytic variants)
Oligodendrogliomas and ependymomas
Meningiomas – develop from the meninges (brain-spine coverings). Usually slow growing and often benign; however, higher-grade types can be more aggressive.
Medulloblastomas – aggressive tumours more common in children, rare in adults.
Other less common tumours include schwannomas, craniopharyngiomas, gangliogliomas, and more.
Symptoms vary based on tumour type, size, and location, and may include:
Frequent headaches, seizures, balance issues, vision or cognitive changes
Back or neck pain, limb weakness, or sensory changes for spinal tumours
When tumours compress nearby structures, even benign ones can be life-threatening.
Imaging (MRI, CT scans) is the primary tool for detection
Biopsy confirms tumour type and grade, which guides treatment. However, biopsy for CNS tumours is often done as part of surgical removal if possible. Otherwise, stereotactic image-guided biopsy is carried out.
Treatment options are tailored to tumour characteristics and may include:
Surgery to remove or reduce the tumour mass.
Radiation therapy, including stereotactic radiosurgery.
Chemotherapy and targeted therapies, especially for aggressive types like glioblastoma.
Supportive care, such as steroids for swelling or anticonvulsants for seizures.