Neurological Cancers (Brain & Spinal Cord)

Neurological cancers, also referred to as central nervous system (CNS) tumours, arise in the brain or spinal cord. These can be:

  • Primary tumours, originating in CNS tissues;

  • Secondary (metastatic) tumours, spreading from cancers elsewhere in the body. 

Many of these tumours are non-cancerous, but even non-cancerous tumours can be dangerous due to their growth within delicate neural structures.

 

Types & Classification

CNS tumours are grouped largely by their cellular origin, which influences treatment and prognosis. Common types include:

  • Gliomas – originate from glial cells and account for around 30% of all CNS tumours and 80% of malignant ones. Subtypes include:

  • Astrocytomas (e.g., glioblastoma, pilocytic variants)

  • Oligodendrogliomas and ependymomas

  • Meningiomas – develop from the meninges (brain-spine coverings). Usually slow growing and often benign; however, higher-grade types can be more aggressive.

  • Medulloblastomas – aggressive tumours more common in children, rare in adults.

  • Other less common tumours include schwannomas, craniopharyngiomas, gangliogliomas, and more.

 

Signs & Symptoms

Symptoms vary based on tumour type, size, and location, and may include:

  • Frequent headaches, seizures, balance issues, vision or cognitive changes

  • Back or neck pain, limb weakness, or sensory changes for spinal tumours

When tumours compress nearby structures, even benign ones can be life-threatening.

 

Diagnosis & Treatment
  • Imaging (MRI, CT scans) is the primary tool for detection 

  • Biopsy confirms tumour type and grade, which guides treatment. However, biopsy for CNS tumours is often done as part of surgical removal if possible. Otherwise, stereotactic image-guided biopsy is carried out.

  • Treatment options are tailored to tumour characteristics and may include:

  • Surgery to remove or reduce the tumour mass.

  • Radiation therapy, including stereotactic radiosurgery.

  • Chemotherapy and targeted therapies, especially for aggressive types like glioblastoma.

  • Supportive care, such as steroids for swelling or anticonvulsants for seizures.